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Inorg Chem. 2021 Jun 15. doi: 10.1021/acs.inorgchem.1c01138. On-line forward of print.
Within the seek for potential new metal-based antitumor brokers, two sequence of nonclassical palladium(II) pincer complexes primarily based on functionalized amides with S-modified cysteine and homocysteine residues have been ready and absolutely characterised by 1D and 2D NMR (1H, 13C, COSY, HMQC or HSQC, 1H-13C, and 1H-15N HMBC) and IR spectroscopy and, in some circumstances, X-ray diffraction. A lot of the ensuing complexes exhibit a excessive stage of cytotoxic exercise in opposition to a number of human most cancers cell strains, together with colon (HCT116), breast (MCF7), and prostate (PC3) cancers. Among the compounds into account are additionally environment friendly in each native and doxorubicin-resistant reworked breast cells HBL100, suggesting the prospects for the creation of therapeutic brokers primarily based on the associated compounds that will be capable to overcome drug resistance. An evaluation of various facets of their organic results on residing cells has revealed a exceptional skill of the S-modified derivatives to induce cell apoptosis and environment friendly mobile uptake of their fluorescein-conjugated counterpart, confirming the excessive anticancer potential of Pd(II) pincer complexes derived from functionalized amides with S-donor amino acid pendant arms.